We use MySQL databases, but definitely not to make the game run faster. They are a lot slower than Rapture's native databases due to the fact that Rapture's dbs are memory resident and are built to sacrifice memory space for the sake of speed. RAM is dirt-cheap, after all, so who cares.
What we use them for, however, is storing data that we need to expose to processes outside the game or data that just doesn't need to be accessed frequently (registration data, player-written books, etc).
--matt
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