Well, insofar as all organizations of people are organizations of people, they're the same. But, two of the most important aspects of guilds - that they controlled access to classes and that only a single class was allowed per guild - have been removed. Houses allow multiple classes within, have a more flexible leadership structure, and soon will have direct influence over city governments. They'll also be working on establishing House icons (if they wish) that grant various benefits to House members, and will provide for player vs. player conflict insofar as the Icons are attackable by other players.
--matt
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