A point to consider: Roleplaying requires interaction, and the more spread out the players are, the less interaction there's going to be. Will players be able to use teleporter devices to get together (stargates, beaming people around, etc)? Will they interact virtually (some sort of holodeck, cyberspace, etc)? Or will the roleplaying take part via communication devices? Or perhaps the roleplaying parts of the game take place at a particular location, with the rest of the universe used for other gamers (explorers, etc)?
But if you're going to have 100k stars and planets then presumably you're going to be using on-the-fly generated content anyway - so why have a fixed limit at all? Elite II, for example, had around 200 billion solar systems, each with up to 20 planets - yet the game itself came on a single floppy disk. I believe there are around 100 billion stars in our Milky Way galaxy, so it's certainly something you might want to consider (particularly as you seem to be trying to create a simulation).
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