I keep my global file CHMOD to 644 just in case, but I also user an older (1.3.1) version of the board. I can still make general changes, but global masks and such require the global file to be set at 666 for changes.
I did get hit by a worm once, which I got rid of and checked the permissions on all my files. Other than that I've had no problems and as long as you have everything CHMOD correctly, it should be fine.
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